Godard MP, Johnson BA, Richmond SR. J Pharmacol Exp Ther 2005;312(2):849-856. Choose a spot that is protected from wind. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using. Seed and seed rate When taken by mouth, coleus is used to treat allergies, dry eye, skin conditions such as eczema and psoriasis, obesity, painful menstrual periods, irritable bowel syndrome (IBS), urinary tract infections (UTI), bladder infections, advanced cancer, blood clots, sexual problems in men, trouble sleeping (insomnia), and convulsions. Knowledge of the regulatory principles of one secondary pathway could help us in future to understand why some cultures do not produce the secondary compounds which are found in the plant. Hypertension 1998;31(3):872-877. Bersudsky, Y., Kotler, M., Shifrin, M., and Belmaker, R. H. A preliminary study of possible psychoactive effects of intravenous forskolin in depressed and schizophrenic patients. Anesthesiology 2003;99(1):18-26. Later, Brown (1810) reclassified this species as Plectranthus scutellarioides, and this name was also used by Blume (1826) for another specimen which was similar to the one of Linnaeus. Damanik, R., Wahlqvist, M. L., and Wattanapenpaiboon, N. Lactagogue effects of Torbangun, a Bataknese traditional cuisine. View abstract. Plan: To review literature on the medicinal value of Coleus forskohlii Prologue: Coleus forskohlii is an aromatic plant belonging to the family Lamiaceae. Thromb Haemost 1989;61:106-10. J Asian Nat Prod Res 2006;8(4):355-360. The only style has two stigmas. J Ocul Pharmacol Ther. These preparations are being promoted for the same conditions for which forskolin has been traditionally used. Coleus forskohlii. Forskolin is a chemical found in the roots of the coleus plant. In an induction medium which promotes differentiation in direction of root formation, root-like structures are formed and forskolin accumulation can be observed. View abstract. View abstract. View abstract. Solenostemon scutellarioides is the long Latin name for the species we know as Coleus. Heart disease: Forskolin, a chemical found in coleus, might lower blood pressure. Dubey, M. P., Srimal, R. C., Nityanand, S., and Dhawan, B. N. Pharmacological studies on coleonol, a hypotensive diterpene from Coleus forskohlii. Low blood pressure: Forskolin, a chemical found in coleus, might lower blood pressure. View abstract. It also acts as an anti-inflammatory drug, and may be used to treat thromboembolic platelet disorders and tumor metastases of certain cancers. In the beginning, the juice obtained from the roots of the plant was used to cure constipation in children, and later on the decoction of roots was used as tonic ( Singh et al., 2011b ). Matsumoto, S., Yamashita, T., Araie, M., Kametani, S., Hosokawa, T., and Takase, M. The ocular penetration of topical forskolin and its effects on intraocular pressure, aqueous flow rate and cyclic AMP level in the rabbit eye. J Cardiovasc.Pharmacol 1992;19(5):779-789. View abstract. Cancer 1990;65:446-51. When inhaled, coleus can cause throat irritation, cough, tremor, and restlessness. Technical production of RA in cell cultures of C. blumei could be economically feasible. This plant requires regular fertilizing. Taking coleus along with medications for high blood pressure might cause your blood pressure to go too low. The information in this website has been compiled from reliable sources, such as reference works on medicinal plants. Members of the genus Coleus produce interesting secondary compounds from very different classes, e.g., C. blumei synthesizes rosmarinic acid and C. forskohlii forskolin, which belong to the caffeic acid esters and the diterpenoids respectively. Forskolin compared with beclomethasone for prevention of asthma attacks: a single-blind clinical trial. J Ethnopharmacol 2000;73(1-2):53-60. The first description of this plant was by Linnaeus (1763), who gave the name Ocimum scutellarioides. The production of forskolin by in vitro cultures of C. forskohlii can yield about the same amounts of forskolin in the dry mass as the wild-growing plant, therefore this procedure might become feasible if the productivity could be further optimized. The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release. ... if rather terse, guide to the traditional medicinal uses of the plants of the region, 1346. Oral Administration of Forskolin, Homotaurine, Carnosine, and Folic Acid in Patients with Primary Open Angle Glaucoma: Changes in Intraocular Pressure, Pattern Electroretinogram Amplitude, and Foveal Sensitivity. They have square stems, opposite, toothed, stalked, or stalkless leaves and asymmetrical flowers. Therefore this name is also used in this chapter. Planta Med 1996;62(2):169-172. Caprioli, J., Sears, M., Mead, A., Kosley, R. W., Jr., Cherill, R. J., Hugher, F. P., Allen, R. C., and Tressler, C. Adenylate cyclase stimulation and intraocular pressure reduction by forskolin analogs. Healthcare providers sometimes give coleus intravenously (by IV) for heart failure. Forskolin, which was detected only quite recently as a promising drug because of its activity towards adenylate cyclase, is used as a research tool for studying the function of this enzyme. View abstract. Wong, S., Mok, W., Phaneuf, S., Katz, S., and Salari, H. Forskolin inhibits platelet-activating factor binding to platelet receptors independently of adenylyl cyclase activation. Arch Int Pharmacodyn.Ther. Since C. forskohlii up to now is the only known plant source for forskolin, this has led to a severe depletion of the plant, and C.forskohlii is listed as one of the endangered plant species in India. Hepatic cytochrome P450 mediates interaction between warfarin and Coleus forskohlii extract in vivo and in vitro. 2010;38(2):661-8. J Cardiovasc Pharmacol 1990;16:93-100. In India, C. forskohlii is now being cultivated in fields on a large scale to obtain the plant material for the isolation of forskolin. Keep in mind that natural products are not always necessarily safe and dosages can be important. Coleus is a plant that has been used since ancient times to treat heart disorders such as high blood pressure and chest pain (angina), as well as respiratory disorders such as asthma. The appropriate dose of coleus depends on several factors such as the user's age, health, and several other conditions. Forskolin lowers intraocular pressure by reducing aqueous inflow. View abstract. The name Coleus is derived from the Greek work koleos, which means sheath. Treatment of glaucomatous patients by means of food supplement to reduce the ocular discomfort: a double blind randomized trial. View abstract. 2012;64(12):1793-801. It activates the catalytic subunit of the enzyme adenylate cyclase in eukaryotes, and also potentiates the hormonal response of this enzyme in a new and unique manner. Jagtap M, Chandola HM, Ravishankar B. If the production of forskolin by cell or organ cultures could be further optimized, these in vitro cultures might become a further source for forskolin besides field-grown plants. Water the plant thoroughly after planting. View abstract. 2005;20(3):229-236. View abstract. Varieties Maimul, Manganiperu, Garmai are some of the popular varieties. View abstract. 2012;54(1 Suppl 4):77-82. The plant-derived forskolin is used as basic molecule for semisynthetic derivatives. Topical forskolin (colforsin) and aqueous flow in humans. Black Dragon. (Makandi) in hypertension of geriatric population. It is not a substitute for medical advice or treatment and NParks does not purport to provide any medical advice. Some people breathe in (inhale) coleus powder for asthma. 2016 Apr;32(3):178-83. J Ocul Pharmacol Ther. Up to now, none of the mentioned secondary compounds which can be produced by in vitro cultures of Coleus are in any commercial use as pure substances. Baumann G, Felix S, Sattelberger U, Klein G. Cardiovascular effects of forskolin (HL-362) in patients with idiopathic congestiv cardiomyopathy. View abstract. Christenson JT, Thulesius O, Nazzal MM. The genus Coleus was first described by de Loureiro in 1790. Soil and Climate Well drained red loamy soils are suited for cultivation. The interesting activity of forskolin and semisynthetic derivatives on adenylate cyclase and the resulting multiple pharmacological activities are still under investigation. Basic Res Cardiol. Coleus Forskohlii is a plant. This plant is native to areas in the lower elevations of India. Mutolo MG, Albanese G, Rusciano D, et al. 2015;7(11):9508-22. Comparison of 2 doses with fenoterol and placebo]. - Herbal Medicine - An illustrated compilation of Philippine medicinal plants by Dr Godofredo Umali Stuart with botanical information, chemical properties, folkloric uses and medicinal research studies. Therefore, it may be used to treat congestive heart failure. It has been used for over 3,000 years in Ayurvedic Medicine. 2006 Mar-Apr;34(2):200-7. 1995;11(3):173-176. The production of forskolin by in vitro cultures is under investigation only for some years now and further optimization of the culture systems might lead to higher contents of forskolin. Coleus forskohlii has traditionally been used t o treat hypertension, congest ive heart failure, and angina. Yakugaku Zasshi 2005;125(5):449-453. Coleus has Anti Hypertensive Health Benefit View abstract. Clin Pharmacol Ther 1993;53:76-83. The sap, or a decoction of the plant, is used as an abortivum and emmenagogue, and to treat haemorrhoids, inflamed eyes and boils Medicinal and Aromatic Plants. In 1896, Siebert and Voss placed C. blumei, C. scutellarioides, C. atropurpureus, C. bicolor, C. verschaffelti, and C. hybridus as subspecies into the species C. scutellarioides. is an important medicinal plant native to India. A comparative study with dobutamine and sodium nitroprusside. Coleus blumei is not used for medicinal purposes but there is Lancet 1983;1:958-60. Since the acute toxicity of forskolin is much lower than the therapeutic range, this compound or semi-synthetic derivatives may be promising drugs of the future. J Cyclic Nucleotide Res 1981;7:201-24. Forskolin and rutin prevent intraocular pressure spikes after Nd:YAG laser iridotomy. Short communication. It is perennial. Eur J Pharmacol 3-15-1993;245(1):55-61. Stop using coleus at least 2 weeks before a scheduled surgery. eMedicineHealth does not provide medical advice, diagnosis or treatment. A large-scale production of rosmarinic acid by suspension cultures of C. blumei has been successfully performed with a yield of more than 20% of the cell dry weight as rosmarinic acid. View abstract. Zeng, S., Shen, B., Wen, L., Hu, B., Peng, D., Chen, X., and Zhou, W. Experimental studies of the effect of Forskolin on the lowering of intraocular pressure. Coleus carnosus Hassk. View abstract. Christenson, J. T., Thulesius, O., Owunwanne, A., and Nazzal, M. Forskolin impregnation of small calibre PTFE grafts lowers early platelet graft sequestration and improves patency in a sheep model. Phytother Res 2007;21(11):1105-1108. Best used for Obesity. View abstract. Medicinal Coleus (Coleus forskohlii . Biochem Pharmacol 1-1-1987;36(1):13-20. View abstract. Oral administration of forskolin and rutin contributes to intraocular pressure control in primary open angle glaucoma patients under maximum tolerated medical therapy. Kreutner W, Chapman RW, Gulbenkian A, Tozzi S. Bronchodilator and antiallergy activity of forskolin. View abstract. Coleus subfrutectosus Summerh. Arzneimittelforschung 1981;31:1248-50. 2013;17(8):1117-22. Stay on the safe side and avoid use. The origin and nomenclature of Coleus blumei is not very clear, since different names are currently used for the same species, which might be a natural hybrid with origin in Southeast Asia. Calcium channel blockers are a type of medicine used to decrease blood pressure. Forskolin: a potential antimetastatic agent. The synthesis of forskolin seems to be coupled to some state of differentiation; however, this correlation is not as strict as in other systems, where absolutely no secondary compounds are formed in undifferentiated cells. 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