Reproduction. 2011 Jan 15;250(2):213-20. doi: 10.1016/j.taap.2010.10.026. This condition is known as methemoglobinemia and its severity depends on how much you are exposed to and for how long. Aniline caused mesenchymal tumors in the spleen of rats but not in mice after dietary chronic exposure. activation of the autoimmune-mediated mechanism by which “old” red cells are sequestered and phagocytized in the spleen. However, the molecular mechanism (s) of aniline-induced spleen toxicity is not understood well, previous studies have represented that aniline exposure results in iron overload and initiation of oxidative/nitrosative disorder stress and oxidative damage to proteins, lipids and … Epub 2013 Jan 23. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error, Schematic diagram depicting proposed mechanisms responsible for aniline inducedspleen toxicity. The LOAEL was converted to the equivalent of aniline (7 mg/kg-day) and divided by an uncertainty factor of 1000 (10 for the use of a LOAEL, 10 to account for extrapolation from animal data and 10 to protect sensitive individuals) to derive the RfD. The interaction of diamines and polyamines with the peroxidase-catalyzed metabolism of aromatic amines: a potential mechanism for the modulation of aniline toxicity. See this image and copyright information in PMC. The doses were based on earlier studies that had shown spleen toxicity and carcinogenicity in male rats at 100 mg/kg/day but not at 10 mg/12/kg/day. Rubrivivax benzoatilyticus JA2, an aniline non-degrading bacterium, tolerates high concentrations of aniline and produces extracellular polymeric substance(EPS). 1999;151(iii-ix):1–101. Elevated expression of cyclins, cyclin-dependent kinases (CDKs) and phosphorylation of pRB protein along with increases in A, B and CDK1 as a cell cycle regulatory proteins cyclins, and reduce in CDK inhibitors (p21 and p27) could be critical in cell cycle regulation, which contributes to tumorigenic response after aniline exposure. Cell. The free p50 and p65 and Jun/ Fos dimers translocate into nuclei and regulate transcription of a variety of genes including TNF, IL-1, IL-6 that finally induce inflammatory and fibrosis responses. The wide database on aniline studies and specific investigations point to a low potency and an indirect mechanism of clastogenicity, mediated by erythrotoxicity followed by spleenic toxicity and compensatory extramedullary hematopoesis in the bone marrow of rats. Proteomic data reveal the up-regulation of envelope stress response proteins to aniline exposure. Methaemoglobin formation, mainly induced by Rubrivivax benzoatilyticus JA2, an aniline non-degrading bacterium, tolerates high concentrations of aniline and produces extracellular polymeric substance (EPS). Activation of oxidative stress-responsive signaling pathways in early splenotoxic response of aniline. (. Aniline is toxic by inhalation of the vapour, ingestion, or percutaneous absorption. Male Sprague-Dawley rats were given 0.025, 0.05, 0.1, or 0.2 mmol/kg/d of NB in 0.5 ml of 0.25% agar by gavage for 4 d; control rats received the vehicle only. Khan M.F., Kannan S., Wang J. Activation of transcription factor AP-1 and mitogen-activated protein kinases in aniline-induced splenic toxicity. Present address: Department of Plant Sciences, Avvaiyar Government College for Women, Karaikal, Puducherry U.T-609602, India. Early biochemical events … Sci. aniline hydrochloride. [. The increased production of methemoglobin (MetHb) in erythrocytes (ferrihemoglobin HbFe3+) results from the oxidation of heme iron from the ferrous to the ferric state (Kiese, 1974; McLean et al., 1969). -. | The damaged hemoglobin can not carry oxygen. Perspectives on the mechanism of action of the splenic toxicity of aniline and structurally-related compounds. Singh H, et al. Furthermore, EPS formation to known ESR activators(Triton-X-100, EDTA) suggests that envelope stress possibly regulating the EPS production. 2014;147(4):R105–R117. These investigators concluded that SCE production did not correlate well with oncogenic potential for aromatic amines and azo derivatives In other in vitro studies, aniline did not cause chromosomal damage m V-79 Chinese hamster cells incubated m the presence of a rat liver microsomal activating system (Swenberg et al 1976) As measured by an alkaline elution technique, aniline induced …
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